Acetone → HCID 178481590, Verbindung

HRID 223425Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 223425
[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:4])[CH3:3].CC(C)=O>Cl(O)(=O)(=O)=O.O>[CH2-:2][C:5]([CH3:6])=[O:9].[CH3:4][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:1])[CH3:3]

Komponenten

5

Edukt 2

HCID 180AcetoneHCID 12918841HCID 12918841, Verbindung

Produkt 1

HCID 178481590HCID 178481590, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24247Perchloric AcidKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 1.0 gram of 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4,5-dihydroxy-1-methyl-2-imidazolidinone in 20 ml. of anhydrous acetone were added three drops of 70% perchloric acid. The reaction mixture stood at ambient temperature for sixteen hours, and then was diluted with 100 ml. of water. The white crystalline precipitate was collected by filtration and recrystallized from diethyl ether and hexane to afford 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]4,5-dihydroxy-1-methyl-2-imidazolidinone acetonide. M.P. 157°-159° C. Mass Spectrum M+Theory 295; Found 295.

Aufarbeitung

  1. waitThe reaction mixture stood at ambient temperature for sixteen hours
  2. additionwas diluted with 100 ml
  3. filtrationThe white crystalline precipitate was collected by filtration
  4. customrecrystallized from diethyl ether and hexane

Quellen und Nachweise

ORD-Eintrag
ord-2b8986e1e1d94d508231d76940c60c38
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04354030

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