Ethanol → HCID 68439912, Verbindung

HRID 2235041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2235041
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:22][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:20]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33].[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].C(O)C>O>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:20][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:22]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 444266Maleic AcidHCID 68439913HCID 68439913, Verbindung

Produkt 1

HCID 68439912HCID 68439912, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.

Aufarbeitung

  1. dissolutionwere completely dissolved
  2. waitAfter the solution had been left
  3. temperatureto cool
  4. filtrationthe formed solid was collected through filtration

Quellen und Nachweise

ORD-Eintrag
ord-31725629c7b4403c8215b20a560bee53
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713997B2

Notizen zur Reaktion

Wird geladen…