Trimethyl orthoformate → 6-tert-Butyl-4-methoxymethylene-4H-isoquinoline-1,3-dione

HRID 2236491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236491
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])[CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[CH3:17][O:18][CH:19](OC)OC>CN(C)C=O.C(OC(=O)C)(=O)C>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])[C:8]2=[CH:17][O:18][CH3:19])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 2

HCID 9005Trimethyl orthoformateHCID 426251726-tert-butyl-4H-isoquinoline-1,3-dione

Produkt 1

HCID 686925676-tert-Butyl-4-methoxymethylene-4H-isoquinoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 7918Acetic AnhydrideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

6-tert-Butyl-4H-isoquinoline-1,3-dione (45 mg, 0.21 mmol) is dissolved in N,N-dimethylformamide (1 mL) and acetic anhydride (2 mL). Trimethylorthoformate (0.2 mL) is added and the mixture is heated to 120° C. for 1 hour. The volatiles were removed under vacuum and the residue passed through a column to afford the crude product, is used directly in the next step. MS (ESI): 258.3 (M−1)−1.

Aufarbeitung

  1. customThe volatiles were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2db21f0d9f9e4e1da4c3f22cfbf48305
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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