Water → alpha-(2-Methylpropylidene)pyridine-2-acetonitrile

HRID 223698

Reaktionsgleichung

Reaktionsgleichung von HRID 223698
O.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]#[N:10].[CH:11](=O)[CH:12]([CH3:14])[CH3:13].N1CCCCC1>C1C=CC=CC=1.C(O)(=O)C>[CH3:11][CH:12]([CH3:14])[CH:13]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=1)[C:9]#[N:10]

Komponenten

7

Edukt 4

HCID 962WaterHCID 6561IsobutyraldehydeHCID 8082PiperidineHCID 75959Pyridine-2-acetonitrile

Produkt 1

HCID 90767alpha-(2-Methylpropylidene)pyridine-2-acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 241BenzeneLösungsmittel

Versuchsvorschrift

In a flask equipped with a water separator are placed 7 g of 2-pyridyl acetonitrile, 12.8 g of isobutyraldehyde, 0.9 ml of acetic acid, 0.18 ml of piperidine and 250 ml of dry benzene. The mixture is heated under reflux for 3 hours. After cooling, the reaction mixture is washed with water, the organic phase is dried over sodium sulfate then the solvent is evaporated to dryness.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling
  4. washthe reaction mixture is washed with water
  5. dry with materialthe organic phase is dried over sodium sulfate
  6. customthe solvent is evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-8c24038a3fed4ea884fea50cdda5a581
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04356177

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