Water → 2,3-Dichloro-4-fluorobenzoic acid

HRID 2238509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2238509
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([CH3:9])[CH:5]=[CH:4][C:3]=1[F:10].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=[O:12].[K+].[K+].S(=O)(=O)(O)O.[OH2:27]>C(O)(=O)C>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([F:10])[CH:4]=[CH:5][C:6]=1[C:9]([OH:12])=[O:27]

Komponenten

6

Edukt 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 24502Potassium DichromateHCID 67460080HCID 67460080, Verbindung

Produkt 1

HCID 103307052,3-Dichloro-4-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2,3-dichloro-1-fluoro-4-methylbenzene (0.090 g, 0.5 mmol) was added to a stirred mixture of potassium dichromate (0.284 g, 1 mmol) in acetic acid (1 ml). 97% Sulphuric acid (0.5 ml) was then added slowly to the mixture which was subsequently heated at 100° C. for 2 hrs. After cooling to room temperature, water and ice were added and the green solid thus obtained was filtered off and washed with cold water to afford 2,3-dichloro-4-fluorobenzoic acid (0.056 g, 0.27 mmol) as a white solid.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customthe green solid thus obtained
  3. filtrationwas filtered off
  4. washwashed with cold water

Quellen und Nachweise

ORD-Eintrag
ord-c7130ab5c1c347fb92a2ad3621380524
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07718693B2

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