Diethyl Ether → 5-Ethynyl-2-fluorophenol

HRID 2240929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240929
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C(C)C)(C(C)C)C(C)C)=[CH:4][C:3]=1[OH:20].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CCOCC>C1COCC1>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([OH:20])[CH:4]=1)#[CH:9]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 2724141Tetrabutylammonium FluorideHCID 593053612-Fluoro-5-((triisopropylsilyl)ethynyl)phenol

Produkt 1

HCID 593053355-Ethynyl-2-fluorophenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-fluoro-5-((triisopropylsilyl)ethynyl)phenol is dissolved in THF and tetrabutyl ammoniumflouride is added. The solution is stirred overnight at RT. Et2O is added and the solution is washed with H2O, Brine, dried, and the solvent removed. This material is used without any further purification.

Aufarbeitung

  1. washthe solution is washed with H2O, Brine
  2. customdried
  3. customthe solvent removed
  4. customThis material is used without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-aaa542c5d2664447b8f74091e6b99878
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723368B2

Notizen zur Reaktion

Wird geladen…