Water → HCID 15951607, Verbindung

HRID 2244217Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244217
[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[C:9]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:14]=[CH:13][C:12]([C:15]([N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][N:20]3[C:28]([C:31](=[O:36])C(Cl)(Cl)Cl)=[CH:29][CH:30]=[C:19]3[CH2:18]2)=[O:16])=[CH:11][CH:10]=1.O>O1CCOCC1>[C:9]1([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:10]=[CH:11][C:12]([C:15]([N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][N:20]3[C:28]([C:31]([NH:1][CH2:2][C:3]4[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=4)=[O:36])=[CH:29][CH:30]=[C:19]3[CH2:18]2)=[O:16])=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 310183-PyridinemethanamineHCID 68687571HCID 68687571, Verbindung

Produkt 1

HCID 15951607HCID 15951607, VerbindungAusbeute 10,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 0.216 g (0.002 mol) of 3-aminomethylpyridine and 0.508 g (0.001 mol) of 1-[10-(1,1′-biphenyl-4-ylcarbonyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]-2,2,2-trichloroethanone of Step B in 25 mL of 1,4-dioxane was heated overnight under reflux with stirring. The cooled reaction mixture was poured into 200 mL of water. The solid was collected and dried to provide the title compound (0.053 g).

Aufarbeitung

  1. temperatureunder reflux
  2. customThe cooled reaction mixture
  3. customThe solid was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-683060a84f2f43ee9fd61a4a543bcdbe
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678787B2

Notizen zur Reaktion

Wird geladen…