4-Methyl-1-(4-pyridinyl)-2-piperazinone → 4-Methyl-1-(piperidin-4-yl)piperazin-2-one

HRID 2245008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2245008
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][C:8]2=[O:14])=[CH:3][CH:2]=1>CC(O)=O.O=[Pt]=O>[CH3:13][N:10]1[CH2:11][CH2:12][N:7]([CH:4]2[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]2)[C:8](=[O:14])[CH2:9]1

Komponenten

4

Edukt 1

HCID 210505594-Methyl-1-(4-pyridinyl)-2-piperazinone

Produkt 1

HCID 684186724-Methyl-1-(piperidin-4-yl)piperazin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 1-(pyridin-4-yl)-4-methyl-2-piperazinone (12 mg, 0.063 mmol) and PtO2 (49 mg) in HOAc (6.0 mL) was hydrogenated on a Parr shaker under 40 psi for 3 days. The mixture was filtered through celite. The filtrate was concentrated in vacuo. The residue was dissolved in 1N HCl (5.0 mL). The solution was then concentrated in vacuo to give the titled compound as hydrochloride salt (12 mg). MS 198.5 (M+H).

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo
  3. dissolutionThe residue was dissolved in 1N HCl (5.0 mL)
  4. concentrationThe solution was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cfba475646ab4d9e938d997b90383664
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678913B2

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