Hydrazine hydrate (1:1) → Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

HRID 224897

Reaktionsgleichung

Reaktionsgleichung von HRID 224897
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([N+:14]([O-])=O)[CH3:13].O.NN>[Ni+2]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([CH3:17])([CH3:13])[NH2:14]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 126196615-Bromo-3-(2-methyl-2-nitropropyl)indole

Produkt 1

HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 934Nickel cationKatalysator

Versuchsvorschrift

5-Bromo-3-(2-methyl-2-nitropropyl)indole, 5.9 g. was reduced with Raney nichel and hydrazine hydrate according to the method of Procedure 67D. The crude product was purified by dissolving in 200 ml. of dilute hydrochloric acid, treatment with activated charcoal, filtering, and basification of the filtrate with 10% aqueous sodium hydroxide. Yield 3.8 g. of white powder, m.p. 150°-155° C.

Aufarbeitung

  1. customThe crude product was purified
  2. dissolutionby dissolving in 200 ml
  3. filtrationof dilute hydrochloric acid, treatment with activated charcoal, filtering

Quellen und Nachweise

ORD-Eintrag
ord-1e15576f9e24402ea73d6f066ceafe14
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04234595

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