4-Nitrobenzamide → 4-Aminobenzamide

HRID 225201

Reaktionsgleichung

Reaktionsgleichung von HRID 225201
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:10])=[O:9])=[CH:6][CH:5]=1

Komponenten

4

Edukt 1

HCID 120914-Nitrobenzamide

Produkt 1

HCID 760794-AminobenzamideAusbeute 105,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 100 ml of absolute ethanol, 8.35 g of the compound of Example II was hydrogenated over 2 spatulas-full of 10% Pd/C in a Parr apparatus at ca 40 lbs/in2 for 3-4 hrs. Under a nitrogen blanket, the catalyst was filtered off through a Celite pad (sintered glass funnel), which was washed with two volumes of ethanol. Evaporation gave ca 7.2 g of a brown oil.

Aufarbeitung

  1. customin2 for 3-4 hrs
  2. filtrationUnder a nitrogen blanket, the catalyst was filtered off through a Celite pad (sintered glass funnel), which
  3. washwas washed with two volumes of ethanol
  4. customEvaporation

Quellen und Nachweise

ORD-Eintrag
ord-3b2ae0a86cb24970997363fb693d602b
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04235969

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