5-Aminoimidazole-4-carboxamide hydrochloride → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxamide

HRID 225255

Reaktionsgleichung

Reaktionsgleichung von HRID 225255
Cl.[NH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[C:8]([NH2:10])=[O:9].CN(C)[CH:13]=[CH:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1)=O.C([O-])(=O)C.[Na+]>C(O)(=O)C>[F:24][C:23]([F:25])([F:26])[C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:15]2[N:4]3[CH:5]=[N:6][C:7]([C:8]([NH2:10])=[O:9])=[C:3]3[N:2]=[CH:13][CH:14]=2)[CH:18]=1

Komponenten

5

Edukt 3

HCID 661465-Aminoimidazole-4-carboxamide hydrochlorideHCID 517045Sodium AcetateHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

Produkt 1

HCID 146774714-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 1.62 g. of 4-amino-5-imidazolecarboxamide hydrochloride, 2.43 g. of 3-dimethylamino-3'-trifluoromethylacrylophenone and 0.82 g. of sodium acetate in 25 ml. of glacial acetic acid is refluxed for 15 hours and then evaporated to dryness. The residue is treated as described in Example 1, giving the desired product, m.p. 239°-240° C.

Aufarbeitung

  1. additionA mixture of 1.62 g
  2. customevaporated to dryness
  3. additionThe residue is treated

Quellen und Nachweise

ORD-Eintrag
ord-c4aca6425bf1473183d71155aea10868
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04236005

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