N,N-Dimethylaniline → HCID 19383098, Verbindung

HRID 2254118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2254118
P(Cl)(Cl)([Cl:3])=O.CN(C)C1C=CC=CC=1.[F:15][C:16]([F:29])([F:28])[C:17]1[NH:26][C:25](=O)[C:24]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[N:18]=1.C(OCC)C>C1(C)C=CC=CC=1.O>[Cl:3][C:25]1[C:24]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[N:18]=[C:17]([C:16]([F:29])([F:28])[F:15])[N:26]=1

Komponenten

7

Edukt 4

HCID 949N,N-DimethylanilineHCID 3283Diethyl EtherHCID 24813Phosphorus oxychlorideHCID 1357422392-(Trifluoromethyl)-5,6,7,8-tetrahydroquinazolin-4-ol

Produkt 1

HCID 19383098HCID 19383098, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a mixture of 6.0 mL of phosphorus oxychloride and 1.0 mL of dimethylaniline in 20 mL of toluene was added 3.0 g of 5,6,7,8-tetrahydro-2-trifluoromethyl-4-quinazolone. The resulting mixture was refluxed for 3 hours and then cooled to room temperature. The reaction mixture was poured into a ice cold mixture of diethyl ether and water. The organic layer was recovered washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to yield the product as a brown solid (3.46 g).

Aufarbeitung

  1. temperatureThe resulting mixture was refluxed for 3 hours
  2. customThe organic layer was recovered
  3. washwashed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-a70defb6d06048fa94e214d6e5ba3dee
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05234936

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