Acetic Acid → 2,4-Bis(trifluoromethyl)phenylacetic acid

Reaktionsgleichung

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:4]=1[C:5]#N.OS(O)(=O)=O.O.[C:23]([OH:26])(=[O:25])C>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:4]=1[CH2:5][C:23]([OH:26])=[O:25]

Komponenten

Edukt 4

HCID 176Acetic Acid

HCID 962Water

HCID 1118Sulfuric Acid

HCID 27361172,4-Bis(trifluoromethyl)benzonitrile

Produkt 1

HCID 27361722,4-Bis(trifluoromethyl)phenylacetic acid

Reaktionsbedingungen

Temperatur: 120 °C

Versuchsvorschrift

2,4-Bis(trifluoromethyl)benzonitrile (41.5 mmol, 10.51 g) was taken up in 100 mL acetic acid, 50 mL conc. H2SO4, and 20 mL water. This was heated to 120° C. for 3 h. The reaction was then diluted with 1 L ice water, and extracted with 2×300 mL ethyl acetate. The combined organics were washed with 2×200 mL water, dried with brine and Na2SO4, and evaporated under reduced pressure. The residue was taken up in a minimum of diethyl ether and crystallized by adding sufficient hexane to precipatate the product. The solid was collected to give 7.74 g of 2,4-bis(trifluoromethyl) phenyl acetic acid as white crystals, 68.5%.NMR 1H (CDCl3) δ7.93 (s,1H), 7.80 (d, J=7.9 Hz,1H), 7.55 (d, J=7.9 Hz,1H), 3.94 (s,2H).