1-Dodecanol → L-lactide epsilon-caprolactone

HRID 2258

Reaktionsgleichung

Reaktionsgleichung von HRID 2258
C(O)CCCCCCCCCCC.[CH3:14][CH2:15][CH2:16][CH2:17][CH:18]([C:21]([O-:23])=[O:22])[CH2:19]C.CCC[CH2:27][CH:28]([C:31]([O-:33])=[O:32])CC.[Sn+2]>>[C:21]1(=[O:23])[O:22][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[CH3:27][C@@H:28]1[O:23][C:21](=[O:22])[C@H:18]([CH3:19])[O:33][C:31]1=[O:32]

Komponenten

3

Edukt 2

HCID 81931-DodecanolHCID 93182-ethylhexanoic acid tin(II) salt

Produkt 1

HCID 131710947L-lactide epsilon-caprolactone

Versuchsvorschrift

The procedure in Example 1 was substantially repeated, except that 13.6 mL of 1-dodecanol instead of 4.00 mL of glycerol and 0.12 mL (40 μmol) instead of 0.10 mL of stannous octoate solution were used. The copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours to remove any unreacted monomer. The copolymer had an inherent viscosity of 0.15 dL/g in HFIP at 25° C. The copolymer was viscous liquid at room temperature. The molar ratio of PC.L/PLA was found to be 51.5/48.5 by proton NMR.

Aufarbeitung

  1. customThe copolymer was dried under vacuum (0.1mm Hg) at 110° C. for about 16 hours
  2. customto remove any unreacted monomer
  3. customat 25° C
  4. customat room temperature

Quellen und Nachweise

ORD-Eintrag
ord-32f23f9ca43c4245993689b694a4b02b
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728752

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