1-Benzylpiperidin-4-yl acetate → Piperidin-4-yl acetate
Reaktionsgleichung
[C:1]([O:4][CH:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[H][H]>C(O)C.O.[Pd]>[C:1]([O:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2]Komponenten
6
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
10% Pd/C (500 mg) was added to a solution of 1-benzylpiperidin-4-yl acetate [(11 g, 47 mmol), J. Org. Chem. 68(2), 613-616; 2003] in a mixture of ethanol and water (90:10, 110 mL), and the mixture was stirred at 60° C., under 60 psi of hydrogen gas for 18 hours. The reaction mixture was then filtered through Arbocel®, washing through with ethanol, and the filtrate was concentrated in vacuo to afford the title product in 92% yield, 7.2 g.
Aufarbeitung
- filtrationThe reaction mixture was then filtered through Arbocel®
- washwashing through with ethanol
- concentrationthe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-f4fcd0dca9fe4d8b8b55a8c6720cbe8d
- Quelldatensatz
- uspto-grants-2009_07
- Patentnummer
- US07557131B2
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