Bromoacetic Acid → 3-[[6-[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acid

HRID 2258397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2258397
[C:1]([C:4]1C(I)=C(NC(=O)CN2CCNCCNCCNCC2)C(I)=CC=1I)([OH:3])=[O:2].Cl.Cl.Cl.[O:32]=[C:33]([NH:55][C:56]1[C:57]([I:67])=[C:58]([C:62]([I:66])=[CH:63][C:64]=1[I:65])[C:59]([OH:61])=[O:60])[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][NH:39][C:40](=[O:54])[CH2:41][N:42]1[CH2:53][CH2:52][NH:51][CH2:50][CH2:49][NH:48][CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1.Br[CH2:69][C:70]([OH:72])=[O:71]>CCO.O>[C:70]([CH2:69][N:45]1[CH2:46][CH2:47][N:48]([CH2:4][C:1]([OH:3])=[O:2])[CH2:49][CH2:50][N:51]([CH2:4][C:1]([OH:3])=[O:2])[CH2:52][CH2:53][N:42]([CH2:41][C:40]([NH:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][C:33]([NH:55][C:56]2[C:57]([I:67])=[C:58]([C:62]([I:66])=[CH:63][C:64]=2[I:65])[C:59]([OH:61])=[O:60])=[O:32])=[O:54])[CH2:43][CH2:44]1)([OH:72])=[O:71]

Komponenten

6

Edukt 3

HCID 6227Bromoacetic AcidHCID 22921403N-(3-carboxy-2,4,6-triiodophenyl)-1,4,7,10-tetraazacyclododecane-1-acetamideHCID 867511793-[[1-Oxo-6-[[(1,4,7,10-tetraazacyclododec-1-yl) acetyl]amino]hexyl]amino]-2,4,6-triiodobenzoic acid trihydrochloride

Produkt 1

HCID 105584113-[[6-[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acidAusbeute 73,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

According to the procedure described in Example 3, 142.4 g of compound (B) 3-[[1-oxo-6-[[(1,4,7,10-tetraazacyclododec-1-yl) acetyl]amino]hexyl]amino]-2,4,6-triiodobenzoic acid trihydrochloride (0.15 mol ) are reacted with 83.4 g of bromoacetic acid (0.60 mol) in 750 ml of 96% EtOH and 250 ml of H2O. 72.7 g of 3-[[6-[[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]-1-oxohexyl]amino]-2,4,6-triiodobenzoic acid (0.072 mol) are obtained.

Quellen und Nachweise

ORD-Eintrag
ord-c9f6f4e4119f4578a3a7b4104f57b12f
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05660814

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