Isophthalaldehyde → 3-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

HRID 22595

Reaktionsgleichung

Reaktionsgleichung von HRID 22595
[CH:1](=[O:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[CH:3]=1.[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH3:22])=[N:19]2)=[CH:14][CH:13]=1>C(OC(=O)C)(=O)C.CCOCC>[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH:22]=[CH:5][C:4]3[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=3)[CH:1]=[O:10])=[N:19]2)=[CH:14][CH:13]=1

Komponenten

5

Edukt 2

HCID 34777IsophthalaldehydeHCID 1383957-Chloro-2-methylquinoline

Produkt 1

HCID 533948533-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

A solution of isophthalaldehyde (4.0 g) and 7-chloroquinaldine (5.39 g) in acetic anhydride was heated at 125° in an oil bath for 48 hours. The reaction was cooled to room temperature, diluted with ether (30 mL) and the resulting suspension was stirred vigorously. The solid title compound was collected by filtration and was used as such in the next step.

Aufarbeitung

  1. filtrationThe solid title compound was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-82aa24b70650476f8934154e035255ed
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428171

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