Water → Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester

HRID 2263175Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2263175
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14]

Komponenten

5

Edukt 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27374492-Bromo-2'-fluoroacetophenone

Produkt 1

HCID 18526224Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl esterAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-(2-fluorophenyl)ethanone (5.00 g, 23.0 mmol) and potassium thiocyanate (2.24 g, 23.0 mmol) in ethanol (50 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (60 ml) was poured into the reaction solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (4.29 g, 95.5%) as a solid.

Aufarbeitung

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-96725ae2fc564cedb3af24ca0bc94c03
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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