Water → 2-Amino-4,5-dichlorobenzoic acid

HRID 2265170

Reaktionsgleichung

Reaktionsgleichung von HRID 2265170
[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].O.[Li+].[OH-]>C1COCC1>[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 11694243Methyl 2-amino-4,5-dichlorobenzoate

Produkt 1

HCID 121045502-Amino-4,5-dichlorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 2-amino-4,5-dichlorobenzoate (2.1 g, 9.41 mmol) was dissolved in THF (15 mL) and water (30 mL) was added. LiOH (0.79 g, 18.8 mmol) was added the mixture was stirred overnight at rt. The product was precipitated by addition of 10% aq. HCl (30 mL) and isolated by suction filtration. The white solid was dried under vacuum (1.6 g, 81%). 1H NMR (400 MHz, DMSO-d6): 7.78 (s, 1H), 7.01 (s, 1H).

Aufarbeitung

  1. customThe product was precipitated by addition of 10% aq. HCl (30 mL)
  2. customisolated by suction filtration
  3. customThe white solid was dried under vacuum (1.6 g, 81%)

Quellen und Nachweise

ORD-Eintrag
ord-53b126169da841e7a3a20b968616c29c
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855292B2

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