Diethyl Ether → [2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester

{2-[(Cyano-dimethyl-methyl)-amino]-ethyl}-carbamic acid tert-butyl ester (0.74 g., 3.3 mmol) was dissolved in THF (2 mL), cooled in an ice bath, and a 1.0 M solution of LiAlH4 in Et2O (6.5 mL, 6.5 mmol) was added dropwise. The resulting suspension was stirred in the ice bath for 3 h and then quenched (i. 0.17 mL of water; ii. 0.17 mL of 4 M aqueous NaOH; iii. 0.84 mL of water). The resulting mixture was diluted with THF (50 mL) and stirred for 15 min. The mixture was filtered and the filtrate concentrated to give an oil. The oil was dissolved in THF (10 mL), DIPEA (1.4 mL) was added, and the mixture was stirred in an ice bath. A solution of p-nitrophenyl chloroformate (800 mg, 4.0 mmol) in THF (8 mL) was added dropwise and the resulting yellow solution was stirred for 16 h. The mixture was concentrated, dissolved in DCM (50 mL) and washed with 0.5 M HCl (50 mL) followed by saturated aqueous NaHCO3 solution (50 mL). The organic layer was dried (Na2SO4), concentrated and purified by flash chromatography (EtOAc) to give the product as a pale yellow gum (450 mg, 54%).

1. temperaturecooled in an ice bath
2. customquenched (i. 0.17 mL of water; ii. 0.17 mL of 4 M aqueous NaOH; iii. 0.84 mL of water)
3. additionThe resulting mixture was diluted with THF (50 mL)
4. filtrationThe mixture was filtered
5. concentrationthe filtrate concentrated
6. customto give an oil
7. stirringthe mixture was stirred in an ice bath
8. stirringthe resulting yellow solution was stirred for 16 h
9. concentrationThe mixture was concentrated
10. dissolutiondissolved in DCM (50 mL)
11. washwashed with 0.5 M HCl (50 mL)
12. dry with materialThe organic layer was dried (Na2SO4)
13. concentrationconcentrated
14. custompurified by flash chromatography (EtOAc)

ORD-Eintrag

ord-ac0af608a75c421496204be8dd0aea43

Quelldatensatz

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07858785B2