Water → 2-(8-Iodooctyl)-4,5,6,7-tetramethoxyindan

HRID 2268473

Reaktionsgleichung

Reaktionsgleichung von HRID 2268473
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1)(=O)=O.[I-:31].[Na+].O>CC(C)=O>[I:31][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 5238Sodium IodideHCID 183485438-(4,5,6,7-Tetramethoxyindan-2-yl)octyl methanesulfonate

Produkt 1

HCID 183485412-(8-Iodooctyl)-4,5,6,7-tetramethoxyindanAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

The mixture of 8-(4,5,6,7-tetramethoxyindan-2-yl)octyl methanesulfonate (2.36 g), sodium iodide (2.38 g) in acetone (20 ml) was heated under reflux for 3 hr. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo to yield the entitled compound (2.44 g) as an oil.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride
  5. customdried
  6. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-12e43a8690a64c9db37601c105d348df
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06326369B1

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