4-Methyl-5-(2-hydroxyethyl)thiazole → 5-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

HRID 227381

Reaktionsgleichung

Reaktionsgleichung von HRID 227381
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:17][S:18]([O:9][CH2:8][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1])(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Produkt 1

HCID 101049265-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The 4-methyl-5-thiazole ethanol (Aldrich, 0.18 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Quellen und Nachweise

ORD-Eintrag
ord-e3ac47f2f60440cba9fad8d793c7a4e0
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560481B2

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