C[Si]([C:5]#[N:6])(C)C.[OH:7][C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1.[C:15]1(=O)[CH2:18][CH2:17][CH2:16]1.ClCCl>CC(C)=O>[OH:7][C:8]1[CH:14]=[CH:13][C:11]([NH:12][C:15]2([C:5]#[N:6])[CH2:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1Trimethylsilyl cyanide (0.93 ml, 7 mmol) was added dropwise to a mixture of 4-hydroxyaniline (0.545 g, 5 mmol) and cyclobutanone (0.42 g, 6 mmol). The reaction mixture was stirred at room temperature for 6 h and then concentrated under vacuum to obtain a brown liquid which was subjected to chromatography (dichloromethane:acetone, 98:2) to yield 11a (0.903 g, 4.8 mmol, 96%) as a yellowish solid.
Wird geladen…
