(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 2274633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2274633
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

Komponenten

4

Edukt 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

Produkt 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamineAusbeute 100,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate (844 mg, 3.00 mmol) in methanol (50 ml) was added 5% palladium on carbon (30 mg) and the mixture was stirred at room temperature for 2 hr under hydrogen atmosphere. The reaction mixture was filtered on Celite and washed with methanol (200 ml) and the filtrate was concentrated in vacuo to obtain the title compound (442 mg, 100%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered on Celite
  2. washwashed with methanol (200 ml)
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1533697070fc4b1390f48a969b4efd4d
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126981B2

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