Water → HCID 57755833, Verbindung

HRID 227695

Reaktionsgleichung

Reaktionsgleichung von HRID 227695
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[NH2:13])([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15].[OH2:21].N1[CH:27]=[CH:26]C=CC=1>>[C:14]([N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[C:7]([NH:13][C:26](=[O:21])[CH3:27])=[N:8]1)(=[O:16])[CH3:15]

Komponenten

5

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 7918Acetic AnhydrideHCID 31366553-Amino-5-nitroindazole

Produkt 1

HCID 57755833HCID 57755833, VerbindungAusbeute 91 %

Versuchsvorschrift

The product from Step (a) above (3.6 g, 20.2 mmol) was dissolved in pyridine (30 mL), acetic anhydride (4.15 mL, 44 mmol) was added and the mixture was stirred overnight at rt. The red solution was pouted into H2O and the resulting solid was filtered to give the title compunt as a red solid (4.8 g, 91%). NMR 1H NMR (400 MHz, DMSO-D6) δ 11.21 (br s, 1H), 9.08 (s, 1H), 8.46 (s, 2H), 2.51 (s, 3H), 2.23 (s, 3H) (MS m/z 263.2.0 [M+H]+

Aufarbeitung

  1. filtrationthe resulting solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-1a43f481a3d64d9fbdc7114267fb6e72
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560467B2

Verknüpfte Notizen

Wird geladen…