Sodium Dithionite → 3,4-Diamino-5-chloro-benzoic acid methyl ester

To a solution of methyl 4-amino-5-chloro-3-nitrobenzoate (4.29 g, 18.6 mmol) in ethanol (115 mL), water (250 mL) and tetrahydrofuran (200 mL) was added sodium hydrosulfite (80 g, 391 mmol). The reaction was stirred at ambient temperature for two hours. To the reaction was added water (55 mL). After stirring for an additional hour saturated aqueous sodium bicarbonate (140 mL) was added to the reaction. The reaction mixture was filtered and the filtrate was extracted twice with ethyl acetate (200 mL each). The organic extracts were combined and washed with saturated aqueous sodium bicarbonate (100 mL) followed by saturated aqueous sodium chloride (100 mL). The organic layer was concentrated in vacuo to a final volume of 100 mL and then allowed to sit at ambient temperature overnight to give a precipitate. The mixture was filtered and dried under a stream of nitrogen to give methyl 3,4-diamino-5-chlorobenzoate (973 mg, 26%). The filtrate was concentrated in vacuo to give methyl 3,4-diamino-5-chlorobenzoate (2.45 g, 66%). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.11 (d, J=1.95 Hz, 1 H) 7.08 (d, J=1.95 Hz, 1 H) 5.44 (s, 2 H) 5.08 (s, 2 H) 3.70 (s, 3 H).

1. additionwas added to the reaction
2. filtrationThe reaction mixture was filtered
3. extractionthe filtrate was extracted twice with ethyl acetate (200 mL each)
4. washwashed with saturated aqueous sodium bicarbonate (100 mL)
5. concentrationThe organic layer was concentrated in vacuo to a final volume of 100 mL
6. waitto sit at ambient temperature overnight
7. customto give a precipitate
8. filtrationThe mixture was filtered
9. customdried under a stream of nitrogen

ORD-Eintrag

ord-0be4ba5eb70b4b48a44eccff17c7f14e

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09139587B2