1,2-Dibromoethane → 2-Cyano-2-methyl-but-3-enoic acid tert-butyl ester

To a stirred slurry of sodium hydride (60% in mineral oil, 880 mg, 22 mmol) in dry N,N-dimethylformamide (100 mL) at 0° C., under nitrogen, was added dropwise cyano-methyl-acetic acid tert-butyl ester (prepared as in J. Am. Chem. Soc. 2011, 133, 8165, 3.10 g, 20 mmol). Any residual cyano-methyl-acetic acid tert-butyl ester was transferred by washing its original vessel with a little N,N-dimethylformamide and transferring to the reaction mixture. The reaction mixture was allowed to warm to ambient temperature for 40 minutes and then cooled to 0° C. 1,2-Dibromoethane (3.95 g, 1.81 mL, 21 mmol) was added dropwise via syringe pump over 30 minutes. The reaction mixture was stirred at 0° C. for a further 3 h and then allowed to warm to ambient temperature for 1 h. The mixture was poured into water and extracted with ethyl acetate (3×) and the combined organic extracts were washed with water (3×), dried over anhydrous magnesium sulfate, filtered and evaporated. To the residue was added 1,8-diazabicyclo[5.4.0]undec-7-ene (3.14 g, 3.07 mL, 20.6 mmol) and the mixture stirred and heated to 80° C. for 30 minutes and then allowed to cool. Saturated ammonium chloride solution was added and the mixture extracted with diethyl ether (2×). The organic extracts were washed with 0.5 M Hydrochloric acid, saturated sodium bicarbonate solution, saturated brine, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by silica gel chromatography using iso-hexanes/ethyl acetate 19:1 to afford the title compound (3.15 g, 87%) as a pale yellow oil. 1H NMR (300 MHz, CDCl3) δ 1.52 (s, 9H), 1.68 (s, 3H), 5.37 (d, J=10.0 Hz, 1H), 5.63 (d, J=17.0 Hz, 1H), 5.89 (dd, J=17.0, 10.0 Hz, 1H).

1. washby washing its original vessel with a little N,N-dimethylformamide and transferring to the reaction mixture
2. temperaturecooled to 0° C
3. temperatureto warm to ambient temperature for 1 h
4. extractionextracted with ethyl acetate (3×)
5. washthe combined organic extracts were washed with water (3×)
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated
9. stirringthe mixture stirred
10. temperatureheated to 80° C. for 30 minutes
11. temperatureto cool
12. extractionthe mixture extracted with diethyl ether (2×)
13. washThe organic extracts were washed with 0.5 M Hydrochloric acid, saturated sodium bicarbonate solution, saturated brine
14. dry with materialdried over anhydrous magnesium sulfate
15. filtrationfiltered
16. customevaporated
17. customThe residue was purified by silica gel chromatography

ORD-Eintrag

ord-9c7376f16ec846deb80d853137735da8

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09145441B2