Potassium Iodide → Methyl 5-cyano-2-iodobenzoate

HRID 2287345Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2287345
N([O-])=O.[Na+].[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][C:9]=1N.[I-:18].[K+].S([O-])([O-])(=O)=S.[Na+].[Na+]>O.S(=O)(=O)(O)O>[CH3:5][O:6][C:7](=[O:17])[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][C:9]=1[I:18]

Komponenten

7

Edukt 4

HCID 4875Potassium IodideHCID 24477Sodium ThiosulfateHCID 10058039Methyl 2-amino-5-cyanobenzoateHCID 23668193Sodium Nitrite

Produkt 1

HCID 23076822Methyl 5-cyano-2-iodobenzoateAusbeute 85,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel3×HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

Sodium nitrite (0.8 g, 11.4 mmol) in water (10 ml) was added dropwise over 10 minutes to a stirred solution of 2-amino-5-cyanobenzoic acid methyl ester (2.0 g, 11.4 mmol) in water (30 ml) and conc. sulphuric acid (15 ml) at 0° C. After a further 15 minutes at 5° C., a solution of potassium iodide (3.5 g, 21 mmol) in water (30 ml) was quickly added and the mixture allowed to warm to room temperature. 10% Aqueous sodium thiosulphate was added, the mixture extracted with ethyl acetate, the extract dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane to yield the title compound as a colourless oil (2.8 g). MS (+EI) m /z 287 [M+ ].

Aufarbeitung

  1. extractionthe mixture extracted with ethyl acetate
  2. dry with materialthe extract dried over magnesium sulphate
  3. customevaporated
  4. customThe residue was purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane

Quellen und Nachweise

ORD-Eintrag
ord-40d6ee9a766c434d825462ccc193124e
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06083952

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