Dimethylformamide → 4-(2-chloroethoxy)benzoyl Chloride

HRID 2289157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2289157
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=1.CN(C)C=O.C(Cl)(=O)C([Cl:22])=O>ClCCCl>[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:22])=[O:10])=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 123892684-(2-Chloroethoxy)benzoic acid

Produkt 1

HCID 110748714-(2-chloroethoxy)benzoyl Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

In a 250-ml flask are combined 4-(2-chloroethoxy)benzoic acid (2.58 g, 12.9 mmol), dimethylformamide (0.2 ml) and 1,2-dichloroethane (50 ml). Oxalyl chloride (1.35 ml) is added dropwise and the reaction mixture stirred overnight at room temperature. The reaction becomes homogeneous after stirring several hours. After an overnight stir, the solvent is evaporated to dryness, and the solid product is redissolved in 1,2-dichloroethane (2×50 mL) and evaporated. The product is used as is in subsequent reactions.

Aufarbeitung

  1. customIn a 250-ml flask are combined
  2. stirringafter stirring several hours
  3. stirringAfter an overnight stir
  4. customthe solvent is evaporated to dryness
  5. dissolutionthe solid product is redissolved in 1,2-dichloroethane (2×50 mL)
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-865766fccdd6458aa3d514b217c001c8
Quelldatensatz
uspto-grants-2000_07
Patentnummer
US06090949

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