Water → 3-(6,7-Dimethoxy-quinolin-4-yloxy)-naphthalen-2-ol

Temperatur

130 °C

Naphthalene-2,3-diol (1.00 g), 4-chloro-6,7-dimethoxyquinoline (691 mg), and 4-dimethylaminopyridine (1.14 g) were suspended in o-dichlorobenzene (20 ml), and the mixture was stirred at 130° C. for one hr. The reaction solution was cooled to room temperature, water was then added to the reaction solution, and the mixture was extracted with chloroform. The chloroform layer was then washed with water and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform-methanol to give the title compound (627 mg, yield 58%).

1. temperatureThe reaction solution was cooled to room temperature
2. extractionthe mixture was extracted with chloroform
3. washThe chloroform layer was then washed with water and saturated brine
4. dry with materialwas dried over anhydrous magnesium sulfate
5. customThe solvent was removed by distillation under the reduced pressure
6. customthe residue was purified by column chromatography

ORD-Eintrag

ord-14bf1f949cbb41b0bca79364bb9d621e

Quelldatensatz

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07560558B2