Methanol → HCID 15712257, Verbindung

HRID 2294558Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294558
[C:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].CO.C1COCC1.[BH4-].[Na+]>O>[OH:3][CH:1]([C:4]1[CH:15]=[CH:14][C:7]([C:8]([O:10][CH2:11][CH:12]=[CH2:13])=[O:9])=[CH:6][CH:5]=1)[CH3:2]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 21474599HCID 21474599, Verbindung

Produkt 1

HCID 15712257HCID 15712257, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

3.1 g (15 mmol) of the allyl ester obtained above in (a), 20 ml of methyl alcohol and 20 ml of THF are introduced into a round-bottomed flask. While cooling in an icebath, 285 mg (7.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for one hour. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, then dried over magnesium sulphate and evaporated. 3.1 g (100%) of the expected product are collected in the form of a colorless oil.

Aufarbeitung

  1. additionare introduced into a round-bottomed flask
  2. additionare added in small portions
  3. extractionthe mixture is extracted with ethyl ether
  4. customthe organic phase is separated after settling
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. custom3.1 g (100%) of the expected product are collected in the form of a colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-d881ada2f86d4e69902f2b24ce47c5bb
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688817

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