Acetic Acid → HCID 11287643, Verbindung

HRID 2298436Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2298436
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:3][CH:2]=1.C(O)(=O)C>CO.[Pd]>[NH:1]1[CH2:2][CH2:3][CH:4]([CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:6]1

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 120570091,3-Dimethyl 2-(4-pyridinylmethylene)propanedioate

Produkt 1

HCID 11287643HCID 11287643, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of dimethyl (4-pyridylmethylene)malonate [XXVIIIa] (925 g) in methanol (9 L) was hydrogenated in the presence of glacial acetic acid (360 mL) and 10% palladium on activated carbon catalyst (92.5 g) at 60° C. and 200 psi. The catalyst was filtered off and the resulting solution of the title compound in the form of acetic acid salt was used directly in the next step.

Aufarbeitung

  1. filtrationThe catalyst was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-26afa65d638d4deba309efa9ae0b00e1
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06492522B1

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