Bromine → HCID 178432201, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:12]Br>CC(O)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:10]([Br:12])=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
To a solution of 0.9 g (6.1 mmol) of 2-methyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.16 ml of Br2 (3.1 mmol) dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (20%) Isopropanol/EtOAC) to yield 0.56 g (2.5 mmol, 41%) of the desired product.
Aufarbeitung
- customresulting
- customreaction mixture
- customReaction mixture
- concentrationwas concentrated in vacuo
- custompurified on silica gel column chromatography (20%) Isopropanol/EtOAC)
Quellen und Nachweise
- ORD-Eintrag
- ord-c62e8f97359b49bd9d1915e9459ac660
- Quelldatensatz
- uspto-grants-2002_08
- Patentnummer
- US06436982B1
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