Tetrahydrofuran → HCID 11253685, Verbindung

HRID 2305272

Reaktionsgleichung

Reaktionsgleichung von HRID 2305272
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].[CH3:6][C:7]([CH3:19])([C:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH2:10]1)[CH2:16]2)[OH:8].C(N(CC)CC)C.O1CCCC1>O>[C:1]([O:8][C:7]([C:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH2:10]1)[CH2:16]2)([CH3:19])[CH3:6])(=[O:4])[CH:2]=[CH2:3]

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 3008142-[1-Adamantyl]propan-2-ol

Produkt 1

HCID 11253685HCID 11253685, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A total of 15 mmole of acrylic chloride was added dropwise to a mixture containing 10 mmole of the above-prepared α,α-dimethyl-1-adamantanemethanol, 20 mmole of triethylamine, and 40 ml of tetrahydrofuran, over about 30 minutes. After the completion of addition, the resulting mixture was stirred at room temperature for 6 hours. Water was added to the reaction mixture, and the resulting mixture was concentrated, and the concentrate was subjected to column chromatography on a silica gel to yield the title compound in a yield of 76%.

Aufarbeitung

  1. additionAfter the completion of addition
  2. concentrationthe resulting mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-1b3d027fb53745e88189cc1e0d1f58a2
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06440636B1

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