Water → Ethyl 3-[4-benzyloxyphenyl]-2-butoxypropanoate

HRID 2305319Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2305319
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([OH:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH2:25](Br)[CH2:26][CH2:27][CH3:28].O>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][CH2:25][CH2:26][CH2:27][CH3:28])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8002Butyl bromideHCID 24758Sodium hydrideHCID 151861533-(4-Benzyloxyphenyl)-2-hydroxypropionic acid ethyl ester

Produkt 1

HCID 21930967Ethyl 3-[4-benzyloxyphenyl]-2-butoxypropanoateAusbeute 20 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

A solution of ethyl 3-[4-benzyloxyphenyl)-2-hydroxypropanoate (5.0 g, 16.6 mmol) (prepared in a similar manner as described in Ref: WO95/18125) in dry dimethyl formamide (5 mL) was added to a suspension of sodium hydride (0.1 g, 41.6 mmol) (60% dispersion in oil) in dry dimethyl formamide (3 mL) at 0° C. and stirring was continued for further 1 h. To the above reaction mixture n-butyl bromide (3.4 g, 24.0 mmol) was added at 0° C. and stirring was continued for 10 h at ca. 25° C. Water (30 mL) was added and extracted with ethyl acetate (2×50 mL). The combined ethyl acetate layer was washed with water (50 mL), brine (25 mL), dried (Na2SO4), filtered and the solvent was evaporated. The residue was chromatographed over silica gel using a mixture of ethyl acetate and and pet. ether (1:9) as an eluent to afford the title compound (0.7 g, 20%) as an oil.

Aufarbeitung

  1. stirringstirring
  2. waitwas continued for 10 h at ca. 25° C
  3. extractionextracted with ethyl acetate (2×50 mL)
  4. washThe combined ethyl acetate layer was washed with water (50 mL), brine (25 mL)
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. customthe solvent was evaporated
  8. customThe residue was chromatographed over silica gel using
  9. additiona mixture of ethyl acetate and and pet. ether (1:9) as an eluent

Quellen und Nachweise

ORD-Eintrag
ord-69e0ccbd48af4eaf9cd581a0ea878f38
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06440961B1

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