B(Br)(Br)Br.Cl[C:6]1[N:7]([C:15]2[CH:20]=[C:19]([O:21]C(C)C)[C:18]([Cl:25])=[CH:17][C:16]=2[Cl:26])[N:8]=[C:9]2[C:14]=1[CH2:13][CH2:12][CH2:11][CH2:10]2.O.CCOCC>ClCCl>[Cl:26][C:16]1[CH:17]=[C:18]([Cl:25])[C:19]([OH:21])=[CH:20][C:15]=1[N:7]1[CH:6]=[C:14]2[C:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)=[N:8]1
To a solution of 2.78 g boron tribromide in 5 ml of dichloromethane was added a solution of 3.10 g of 3-chloro-2-(2,4-dichloro-5-isopropoxyphenyl)-4,5,6,7-tetrahydro-2H-indazole VII-1 in 35 ml of dichloromethane under cooling at -78° C. in 15 minutes. The resultant mixture was stirred at -78° C. for 0.5 hours and at room temperature for 1.5 hours and mixed with water and ether at 0° C. The mixture was basified, and the aqueous layer was separated and acidified and shaken with ether. The extract was dried, concentrated and the residue was purified by silica gel chromatography, whereby 2.39 g of the titled compound II-1 was obtained.
Wird geladen…
