Formaldehyde → Indole-2,3-dione, 1-(hydroxymethyl)-

HRID 231031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 231031
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].C=O.[O:14]1CCOC[CH2:15]1>O>[OH:14][CH2:15][N:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 7054IsatinHCID 312751,4-Dioxane

Produkt 1

HCID 39834Indole-2,3-dione, 1-(hydroxymethyl)-Ausbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Isatin (25 g, 0.17 mol) and 30% formalin (30 ml, 0.3 mol) were added to a mixture of dioxane (10 ml) and water (20 ml) and the mixture was heated at 100° C. for 5 hours. The reaction mixture was cooled and crystals formed were filtered off. N-hydroxymethylisatin (28 g, yield 93%) was obtained. The melting point was 138° C. (decomposed).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customcrystals formed
  3. filtrationwere filtered off

Quellen und Nachweise

ORD-Eintrag
ord-e300c7d5fad146689fff82c67bdf00df
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04845020

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