1,4-Dioxane → Methyl 1-(6-chloropyridazin-3-yl)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

Reaktionsgleichung

[CH:18]([N:19]([CH2:20][CH3:21])[CH:22]([CH3:23])[CH3:24])([CH3:25])[CH3:26].[Cl:27][c:28]1[n:29][n:30][c:31]([Cl:34])[cH:32][cH:33]1.[F:1][c:2]1[c:3]([CH:9]2[CH:10]([C:14](=[O:15])[O:16][CH3:17])[CH2:11][NH:12][CH2:13]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1>>[F:1][c:2]1[c:3]([CH:9]2[CH:10]([C:14](=[O:15])[O:16][CH3:17])[CH2:11][N:12]([c:31]3[n:30][n:29][c:28]([Cl:27])[cH:33][cH:32]3)[CH2:13]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1