Isophthalaldehyde → 3-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

HRID 232420

Reaktionsgleichung

Reaktionsgleichung von HRID 232420
[CH:1](=[O:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[CH:3]=1.[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH3:22])=[N:19]2)=[CH:14][CH:13]=1>C(OC(=O)C)(=O)C.CCOCC>[Cl:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH:22]=[CH:5][C:4]3[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=3)[CH:1]=[O:10])=[N:19]2)=[CH:14][CH:13]=1

Komponenten

5

Edukt 2

HCID 34777IsophthalaldehydeHCID 1383957-Chloro-2-methylquinoline

Produkt 1

HCID 533948533-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

A solution of isophthalaldehyde (4.0 g) and 7-chloroquinaldine (5.39 g) in acetic anhydride was heated at 125° C. in an oil bath for 48 hours. The reaction was cooled to room temperature, diluted with ether (30 mL) and the resulting suspension was stirred vigorously. The solid title compound was collected by filtration and was used as such in the next step.

Aufarbeitung

  1. filtrationThe solid title compound was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a09e302a80a04351bff75b030e91b80f
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851409

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