3-Cyclopentyloxy-4-methoxybenzaldehyde → 3-Cyclopentyloxy-4-methoxybenzyl alcohol

HRID 232784

Reaktionsgleichung

Reaktionsgleichung von HRID 232784
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH:10]=[O:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>C(O)C.O>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH2:10][OH:11])[CH2:2][CH2:3][CH2:4][CH2:5]1

Komponenten

5

Edukt 2

HCID 27358933-Cyclopentyloxy-4-methoxybenzaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 111387063-Cyclopentyloxy-4-methoxybenzyl alcoholAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3-cyclopentyloxy-4-methoxybenzaldehyde (38 grams, 0.17 mol) in 40 milliliters of ethanol and sodium borohydride (1.63 grams,0.043 mol) was stirred for 2 hours at room temperature until complete by TLC. The reaction was diluted with water and extracted with ethyl acetate. Evaporation of the ethyl acetate afforded 3-cyclopentyloxy-4-methoxybenzyl alcohol (37 grams, 98%) suitable for the next step.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customEvaporation of the ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e738693e27a54e449d2f0766f81a7cbd
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05591776

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