Water → HCID 54430516, Verbindung

HRID 233491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 233491
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[OH:12][CH2:13][CH2:14][NH:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].[OH2:21]>N1C=CC=CC=1>[CH3:11][C:1]1[CH:6]=[CH:5][C:4]([S:7]([N:15]([CH2:16][C:17]([CH3:20])([OH:19])[CH3:18])[CH2:14][CH2:13][O:12][S:7]([C:4]2[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=2)(=[O:8])=[O:21])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 149870161-[(2-Hydroxyethyl)amino]-2-methyl-2-propanol

Produkt 1

HCID 54430516HCID 54430516, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

4-Toluenesulfonyl chloride (166.1 g) was added portionwise to a stirred solution of 1-[(2-hydroxyethyl)amino]-2-methyl-2-propanol (58.0 g) in pyridine (275 ml) at 0°-10° C. The resulting solution was stirred at room temperature for 15 h and then poured into water (1 l). The mixture was extracted with dichloromethane and the organic phase was washed with hydrochloric acid (2.5M) and brine. After drying over magnesium sulfate, the solvent was removed under reduced pressure to give 1-{N-[(4-methylphenyl)sulfonyl]-N-[(4-methylphenyl)sulfonyloxyethyl]amino}-2-methyl-2-propanol (155.8 g). δ (CDCl3) 1.23 (s,6H), 2.44,2.46 (6H), 3.08 (s,2H), 3.45 (t,2H), 4.35 (t,2H) and 7.25-7.85 (m,8H).

Aufarbeitung

  1. extractionThe mixture was extracted with dichloromethane
  2. washthe organic phase was washed with hydrochloric acid (2.5M) and brine
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0ef93d24f82a486092953910db92c95c
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05593983

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