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Beta-Alanine → HCID 19847267, Verbindung

HRID 2350843
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2350843
C(O)C.[OH-].[K+].[NH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].[N+:12]([C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]([OH:25])=[C:17]([C:26](OC2C=CC=CC=2)=[O:27])[CH:16]=1)([O-:14])=[O:13]>O>[C:9]([CH2:8][CH2:7][NH:6][C:26]([C:17]1[CH:16]=[C:15]([N+:12]([O-:14])=[O:13])[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]=1[OH:25])=[O:27])([OH:11])=[O:10]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 239Beta-AlanineHCID 702EthanolHCID 14797Potassium HydroxideHCID 1033292-Naphthalenecarboxylic acid, 1-hydroxy-4-nitro-, phenyl ester

Produkt 1

HCID 19847267HCID 19847267, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962
Water
Lösungsmittel

Versuchsvorschrift

1,500 ml of ethanol was added to a solution of 56.8 g of potassium hydroxide dissolved in 100 cc of water. 47 g of β-alanine was dissolved into this mixture, and then 132 g of 4-nitro-2-phenoxycarbonyl-1-naphthol was suspended, followed by reflux for 4 hours. After the reaction was completed, the solution was cooled, followed, by filtration of crystal. The obtained crystal was dissolved in 4,000 ml of water. After the insolubles were filtered off, the aqueous solution was neutralized with hydrochloric acid to give yellow crystals. Recrystallization from 5,000 ml of ethanol gave the desired product at a yield of 70%.

Aufarbeitung

  1. temperatureby reflux for 4 hours
  2. temperaturethe solution was cooled
  3. filtrationfollowed, by filtration of crystal
  4. dissolutionThe obtained crystal was dissolved in 4,000 ml of water
  5. filtrationAfter the insolubles were filtered off
  6. customto give yellow crystals
  7. customRecrystallization from 5,000 ml of ethanol

Quellen und Nachweise

ORD-Eintrag
ord-551334c113bc40f7b8a2d5b6854c0308
Quelldatensatz
uspto-grants-1989_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04871655

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