Acetic Anhydride → 4-Acetoxy-2-fluorobenzoic acid

HRID 2357

Reaktionsgleichung

Reaktionsgleichung von HRID 2357
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:12](OC(=O)C)(=[O:14])[CH3:13]>S(=O)(=O)(O)O.O>[C:12]([O:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1)(=[O:14])[CH3:13]

Komponenten

5

Edukt 2

HCID 7918Acetic AnhydrideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

Produkt 1

HCID 227214164-Acetoxy-2-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid was added. After the heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and precipitated crystal was recovered by filtration. The crystal was dried under vacuum and used in a subsequent step. The yield of the crystal was 4.7 g.

Aufarbeitung

  1. additionmixed
  2. additionwas added
  3. customprecipitated crystal
  4. filtrationwas recovered by filtration
  5. customThe crystal was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-83277f5bcbe3453880c179fb06727b5a
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728864

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