Water → 6-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

HRID 2368545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2368545
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[CH:3]=1.[N:15]([O-])=[O:16].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[C:3]=1[N:15]=[O:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 576001846-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Produkt 1

HCID 576001906-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (8.0 g, 0.038 mol) was mixed with sodium nitrite (3.1 g, 0.045 mol) in acetic acid (120 mL). The mixture was stirred at 75° C. for 1 h. The color of the reaction mixture became pink and then purple. The solution was allowed to cool down to room temperature, and water (40 mL) was added. The solid was collected by suction filtration and washed with water (50 mL) to produce the desired product, which was used directly for next step without further purification. LCMS calculated for C9H15N4O2S: (M+H) 243.1. Found 243.1.

Aufarbeitung

  1. temperatureto cool down to room temperature
  2. filtrationThe solid was collected by suction filtration
  3. washwashed with water (50 mL)

Quellen und Nachweise

ORD-Eintrag
ord-3f70140d979b442c9f1daaa3e5cc3819
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08703783B2

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