Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine

HRID 237025

Reaktionsgleichung

Reaktionsgleichung von HRID 237025
[N+](C1C=CC(S([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH2:15][CH2:14]2)(=O)=O)=CC=1)([O-])=O.[OH-].[NH4+].[OH-].[K+]>CCOCC.[Cl-].[Cl-].[Cl-].[Ti+3]>[Cl:25][C:21]1[CH:20]=[C:19]([N:16]2[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]2)[CH:24]=[CH:23][CH:22]=1

Komponenten

6

Edukt 3

HCID 14797Potassium HydroxideHCID 14923Ammonium HydroxideHCID 10197251-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine

Produkt 1

HCID 13551-(3-Chlorophenyl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 10313229titanium(III) trichlorideKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.

Aufarbeitung

  1. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-abb38bd69cbe41e4b74d1fd6d4d564b2
Quelldatensatz
uspto-grants-1979_06
Patentnummer
US04159331

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