Water → HCID 67257850, Verbindung

Temperatur

-65 °C

To a solution of 2,5-dibromo-3-phenylthiophene (2.54 g, 8.0 mmol) in dry THF (30 mL) at −65° C. was added LDA (8.8 mmol) dropwise. After stirring for 30 min at −65° C., oxirane (20.0 mmol) was added and the reaction was stirred for 2 h. The reaction mixture was then warmed to room temperature and water was added. The resulting mixture was extracted with EtOAc (3×100 mL), washed with brine, and dried over anhydrous Na2SO4. After filtration and concentration, the crude product was purified by column chromatography to give the title compound.

1. stirringthe reaction was stirred for 2 h
2. temperatureThe reaction mixture was then warmed to room temperature
3. extractionThe resulting mixture was extracted with EtOAc (3×100 mL)
4. washwashed with brine
5. dry with materialdried over anhydrous Na2SO4
6. filtrationAfter filtration and concentration
7. customthe crude product was purified by column chromatography

ORD-Eintrag

ord-39eb8b49baed460d91e9b42f5f840ba0

Quelldatensatz

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08710245B2