3-Phenoxybenzaldehyde → Cyanide

HRID 2377125

Reaktionsgleichung

Reaktionsgleichung von HRID 2377125
[CH3:1][C:2]1([CH3:31])[C@H:4]([C:5]([O:7][C@@H:8]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]([O:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:16]=2)[C:9]#[N:10])=[O:6])[C@@H:3]1/[CH:24]=[C:25](\[Cl:30])/[C:26]([F:29])([F:28])[F:27].Cl/C(/C(F)(F)F)=C\[C@@H]1[C@H](C(Cl)=O)C1(C)C.O(C1C=C(C=CC=1)C=O)C1C=CC=CC=1>>[C-:9]#[N:10].[CH3:1][C:2]1([CH3:31])[C@H:4]([C:5]([O:7][C@@H:8]([C:11]2[CH:12]=[CH:13][CH:14]=[C:15]([O:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:16]=2)[C:9]#[N:10])=[O:6])[C@@H:3]1/[CH:24]=[C:25](\[Cl:30])/[C:26]([F:27])([F:29])[F:28]

Komponenten

5

Edukt 3

HCID 382843-PhenoxybenzaldehydeHCID 6440554gamma-Cyhalothrin2×HCID 11334477(1RS)-cis-3-(Z-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride

Produkt 2

HCID 5975CyanideHCID 6440554gamma-Cyhalothrin

Versuchsvorschrift

Surprisingly, the applicants have also found it is possible to make gamma-cyhalothrin in a process wherein steps b) and c) can be combined (in a one-pot process), that is a process for the preparation of gamma-cyhalothrin in which 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride (III) is reacted with 3-phenoxy benzaldehyde (IV) and a source of cyanide to give gamma-cyhalothrin (I).

Quellen und Nachweise

ORD-Eintrag
ord-0f901e5ada364bbf86243befb2b08010
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07468453B2

Verknüpfte Notizen

Wird geladen…