Chloromethyl Methyl Ether → HCID 59858077, Verbindung

HRID 2378371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2378371
[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH2:5][C:6]1([CH3:22])[CH2:15][CH2:14][C:13]2[C:8](=[C:9]3[CH:20]4[CH2:21][CH:17]([CH2:18][CH2:19]4)[C:10]3=[C:11]([OH:16])[CH:12]=2)[O:7]1.C(N(C(C)C)CC)(C)C.[CH3:33][O:34][CH2:35]Cl>C(Cl)Cl.[Cl-].[Na+].O>[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH2:5][C:6]1([CH3:22])[CH2:15][CH2:14][C:13]2[C:8](=[C:9]3[CH:20]4[CH2:21][CH:17]([CH2:18][CH2:19]4)[C:10]3=[C:11]([O:16][CH2:33][O:34][CH3:35])[CH:12]=2)[O:7]1

Komponenten

6

Edukt 3

HCID 7864Chloromethyl Methyl EtherHCID 81531DiisopropylethylamineHCID 11716671HCID 11716671, Verbindung

Produkt 1

HCID 59858077HCID 59858077, VerbindungAusbeute 74,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

To a solution of 3-(6-hydroxy-2-methyl-3,4,7,8,9,10-hexahydro-7,10-methano-2H-benzo[h]chromen-2-yl)-propionic acid methyl ester from Example 13 (400 mg, 1.27 mmol) and diisopropyl ethylamine (DIPEA) (0.90 ml, 5 mmol) in 4 mL of DCM was slowly added chloromethyl methyl ether (0.30 mL, 3.8 mmol) at room temperature. The reaction was left over night. After the completion of reaction shown by TLC, the mixture was poured into brine and the organic layer was separated and dried over MgSO4. After the removal of solvents the residue was purified through flash column chromatography on silica gel (25% of ethyl acetate in hexane) to afford 340 mg of 3-(6-methoxymethoxy-2-methyl-3,4,7,8,9,10-hexahydro-7,10-methano-2H-benzo[h]chromen-2-yl)-propionic acid methyl ester. 1H-NMR (300 MHz, CDCl3) δ (ppm)): 6.25 (s, 1H), 4.29 (s, 1H), 3.63 (s, 3H), 2.48 (s, 1H), 3.40 (s, 1H), 2.66-2.64(m, 2H), 2.47-2.43 (m, 2H), 1.83-1.50, (m, 12H), 1.18 (s, 3H).

Aufarbeitung

  1. customat room temperature
  2. waitThe reaction was left over night
  3. customAfter the completion of reaction
  4. customthe organic layer was separated
  5. dry with materialdried over MgSO4
  6. customAfter the removal of solvents the residue
  7. customwas purified through flash column chromatography on silica gel (25% of ethyl acetate in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-d694866ae72c494188e1fdfdbed8cda3
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07470798B2

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