Methyl iodide → 2-Methoxy-4-methylpyridin-3-amine

HRID 2379610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2379610
[N+:1]([C:4]1[C:5](=[O:11])[NH:6][CH:7]=[CH:8][C:9]=1[CH3:10])([O-])=O.[CH3:12]I>[Zn].C(O)(=O)C>[CH3:12][O:11][C:5]1[C:4]([NH2:1])=[C:9]([CH3:10])[CH:8]=[CH:7][N:6]=1

Komponenten

5

Edukt 2

HCID 6328Methyl iodideHCID 3453702-Hydroxy-4-methyl-3-nitropyridine

Produkt 1

HCID 103293612-Methoxy-4-methylpyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

3-Nitro-4-methyl-2-pyridone was methylated with methyl iodide and reduced with zinc and acetic acid to give 2-methoxy-3-amino-4-methylpyridine. This material was coupled with 2-hexylthiodecanoic acid according to the procedure of Example 25 to give the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-f9cfc8b2369347209992578106dab733
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05362878

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