Acetic Anhydride → HCID 10330249, Verbindung

HRID 2379804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2379804
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].C(OCC)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1.O>[C:12]([O:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)(=[O:14])[CH3:13]

Komponenten

7

Edukt 4

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

Produkt 1

HCID 10330249HCID 10330249, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (80 g) and acetic anhydride (198.8 ml) in tetrahydrofuran (800 ml) was heated under reflux for 24 hours. The reaction mixture was added to a mixture of ethyl acetate and water and the mixture was adjusted to pH 8 with potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated to give 6 -acetoxymethyl-2-pyridinecarboxamide (93.34 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. washThe separated organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-00512036dfe14dc0b80275e8e0236b87
Quelldatensatz
uspto-grants-1994_11
Patentnummer
US05364871

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